COVID-19: Hyderabad University professor develops potential vaccine to combat virus

A faculty member of University of Hyderab's Department of Biochemistry has potentially designed a vaccine for coronavirus. vaccine is said to be a T cell epitopes against all 'structural and n-structural proteins of vel coronavirus for experimental testing.'

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Potential vaccine in India

A press release said, "Dr Seema Mishra, faculty of Department of Biochemistry, School of Life Sciences, University of Hyderab (UoH) has designed potential vaccine candidates, called T cell epitopes, against all structural and n-structural proteins of vel coronavirus-2 (2019-nCoV) for experimental testing. se vaccine candidates are small coronaviral peptides, molecules which are used by cells to trigger an immune response to destroy cells harbouring se viral peptides. Using powerful immuinformatics approaches with computational software, Dr Seema Mishra has designed se potential epitopes in a way that can be used to vaccinate entire population."

"Usually, vaccine discovery takes 15 years but powerful computational tools helped in quickly enlisting se vaccine candidates in about 10 days. A ranked list of potential candidate vaccines, based on how much effect y will be used by human cells to stop virus, has been generated. With matches present in human protein pool, se coronaviral epitopes pose cross-reactivity to human cells and hence, immune response will be against viral proteins and t human proteins. However, se results have to be investigated experimentally in order to provide conclusive evidence. se results have been disseminated to scientific community using ChemRxiv preprint platform for urgent experimental assays. se are first such studies on nCoV vaccine design from India exploring whole coronaviral proteome across structural and n-structural proteins that make up virus."

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