Radiation elevates cardiac risk in lung cancer patients: Study

Patients getting treated for locally vanced n-small cell lung cancer (NSCLC) are at a risk of heart attack and heart failure, a recent study has observed. A new retrospective study led by investigators from Brigham and Women's Hospital and Dana-Farber Cancer Institute examined outcomes for patients after receiving treatment for locally vanced NSCLC, finding that aver riation dose delivered to heart was associated with an increased risk of major verse cardiovascular events and death.

According to study published in 'Journal of  American College of Cardiology', aver riation dose delivered to heart was associated with an increased risk of major verse cardiovascular events and death. Among patients who did t have pre-existing coronary heart disease, risk of having a major cardiovascular event after treatment exceeded rates of people considered at high risk of such events.

Raymond Mak, study's senior author said:

"This is alarming data -- to think that one in 10 of patients I'm treating for this of cancer will go on to have a heart attack or or major cardiac event. se cardiac events are happening earlier and more often than previously thought. More patients are living long eugh to experience this risk of cardiac toxicity. We need to start paying attention to this and working toger with cardiologists to help se patients." 

In many cases, a dose of riation to heart is only way for oncologists to treat a patient with lung cancer. 

Katelyn Atkins, le author of study said:

"When treating patients with lung cancer, it's a balance of risks. But we need to start thinking about where re's room for improvement in optimizing treatment for patients and room for improvement in terms of collaborating with primary care physicians and cardiologists."

To conduct ir study, Mak, Atkins, and colleagues analyzed data and outcomes for 748 NSCLC patients treated with thoracic riorapy.

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After treatment, a total of 77 patients (10.3 per cent) experienced a major verse cardiac event, including heart attack and heart failure.  team observed an increased risk of cardiac events with increased doss of heart riation exposure, especially among patients who did t have coronary heart disease before receiving riorapy. Based on ir findings, authors recommended more stringent avoidance of high cardiac riorapy dose and suggested considering a much lower cardiac riation rapy dose limit for patients than national guidelines currently recommend (10 Gy versus 20 Gy).

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Lung cancer is leing cause of cancer deaths worldwide, and half of lung cancer patients will require riation as part of ir care. Previous studies have reported that vances in care, such as screening for lung cancer and treating disease with targeted rapies and immurapies, have improved survival rates for patients. aver survival time is w more than two years for patients with locally vanced NSCLC.