Researches have discovered that dengue virus is resistant to certain vaccinations, as per reports. During study for a new approach to deal with dengue virus, it was found that dengue virus changes its shape through mutations. y tend to alter into envelope protein to eve vaccines and rapeutics.

Study on dengue virus

According to reports, DENV2 (a dengue virus) exists as smooth spherical surface particles while growing at mosquito's physiological temperature of 29 degrees Celsius. It n changes to bumpy surfaced particles at human physiological temperature 37 degrees Celsius. This ability to morph helps virus to eve immune system of human host. Hence, understanding mechanism behind this is important for rapeutics and vaccine development, reported study published in journal, 'PLOS Pathogens'.  research team also tested four DENV2 strains obtained from patients. y observed that in contrast to laboratory-apted viruses, majority of se clinical strains maintained smooth surface structure at 37 degrees Celsius. However, at 40 degrees Celsius, temperature of a fever, all virus strains took on a bumpy surface.

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"Toger with Professor Pei-Yong Shi from UTMB, we found that in laboratory-developed DENV2 strains, mutations in virus' E protein causes its transformation into bumpy particles. se structural changes can cause vaccines and rapeutics to be ineffective against virus," said Ms. Xin-Ni Lim, study's le author who is from Duke-NUS' Emerging Infectious Diseases (EID) Programme.

"Our study gives a new direction to vaccine development and treatment for dengue disease. For prevention of disease through vaccines that are ministered to patient before dengue infection, we should use those that are effective against smooth surface virus," said Dr. Sheemei Lok, Professor, Duke-NUS' EID and corresponding author of this study. "When it comes to patients displaying fever symptoms, treatment strategies effective against bumpy surface particles should be implemented," ded Dr. Lok.

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'Immulogical defences'

"This study is a first step towards gaining more insight into how DENV2 reacts and apts to host's immulogical defences. We were also able to use computational modelling approaches to predict why particles from different DENV2 strains are more or less ept at morphing from smooth to bumpy structures. By better understanding interactions between virus and host, we will be able to develop better rapies and vaccines to treat or prevent infections, and contribute to public health outcomes," said Dr. Peter Bond, Principal Investigator from A*STAR's BII.

study's findings also show that lab apted DENV2 may t be a good model for research, as its structure is different from clinical strains isolated from patients. team is planning to study or DENV seros to find out if re are any or possible structural changes.

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(With ANI inputs)