Dry Eyes: Latest antibody treatment for dry eye syndrome

Dry eye syndrome also called Xeropthalmia at a chronic and vance st, can occur when eyes produce fewer tears or when tears evaporate too quickly which les to inflammation. It is caused by abrmalities in tear fluid and causes dryness over cornea, and a lot of people in today's times suffer from this condition. When dryness persists for a longer time, it can le to severe eye pain and sensitivity to light. A new treatment was discovered by researchers at UIC (University of Illiis at Chicago) that uses human pooled antibodies to target  ACPAs (anti-citrullinated protein autoantibodies) present in human tear fluid. ir early-st clinical trial findings are documented in  Ocular Surface journal.

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What are dry eyes?

A senior author of this study (a UIC professor of ophthalmology and visual sciences at College of Medicine), Dr. Sandeep Jain said that dry eye syndrome is different than having an occasional dryness in eyes. He has mentioned that dry eye syndrome can severely compromise quality of life to point of disability and can compromise a person's vision.

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Dry eye syndrome treatment| How to treat dry eyes

In this research, y found that people using antibody-based eye drops showed substantial corneal dam reduction within eight weeks as well as reduced inflammation on cornea when compared to n-antibody-based eyedrops. Furr trials are going to be conducted to prove efficacy of antibody-based eye drops, so eye drops haven't been released for public yet. However, Dr. Sandeep Jain offers hope and says that data from this early clinical trial suggests that eye drops containing pooled antibodies may be safe and effective for treating dry eye disease.

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How do antibodies work for treating Dry eyes?

new eye drops help by providing relief from inflammation on cornea. Basically, eye drops are formulated using various s of antibodies processed from donated blood of thousands of individuals, this pooled antibodies n counteract  negative effects of ACPAs.

Talking about future of this research, Dr. Sandeep Jain, goal is to conduct a larger randomized trial to prove  efficacy of eye drops. Currently, re are only two approved drugs for dry eye syndrome treatment which don't even work for everyone, especially those with severe disease. So, a new drug that targets a different mechanism (autoimmunity in this case) is very important. Check out article here.

(Source: NCBI: Pathological consequences of anti-citrullinated protein antibodies in tear fluid and rapeutic potential of pooled human immune globulin-eye drops in dry eye disease. Journal -  Ocular Surface, 10 October 2019)