Published 16:03 IST, December 27th 2020

Coronavirus's interaction with proteins in human cells decoded by Scientists

The study will help improve the understanding of the immune response triggered in the host body and how the viral RNA functions.

Reported by: Vishal Tiwari
Follow: Google News Icon
  • share
null | Image: self
Advertisement

Scientists have decoded how COVID-19 virus interacts with proteins in human cells during infection. study will help improve understanding of immune response triggered in host body and how viral RNA functions. Researchers have identified up to 104 human proteins that directly and specifically bind to COVID-19 virus. Researchers used RNA antisense purification and mass spectrometry, an analytical technique, to identify se proteins. 

Read: People Recovered From COVID Get Immunity For 8 Months, Vaccines May Extend Duration: Study

Advertisement

How will study help?

Researchers discovered that cellular nucleic acid-binding protein (CNBP) and La-related protein 1 (LARP1), two "strongly enriched viral RNA binders", restrict COVID-19 virus from replicating in infected cells. It also helped researchers provide a map of exact location of virus inside host cells. study may help develop new treatments against COVID-19 disease.  

Read: Study Sheds Light On Critical Windows In Pregnancy For COVID-19 Vaccination

Advertisement

"A detailed understanding of molecular interactions and perturbations occurring during SARS-CoV-2 infection is required to understand biology of SARS-CoV-2 and design rapeutic strategies. We sought to obtain an unbiased and quantitative picture of cellular proteins that directly bind to SARS-CoV-2 RNAs in infected human cells. Recent RNA capture and quantitative mass spectrometry (MS) approaches applied ultraviolet (UV) crosslinking to create covalent bonds between RNA molecules and proteins y directly interact with," study said. 

Read: Russia Cuts Size Of COVID-19 Vaccine Study, Stops Enrollment

research published in journal Nature Microbiology said that study will help in understanding how virus multiplication occurs in host cells and specifically which ones are helping in replication process, It will also shed a light on how immune response in infected host is activated and exactly which ones trigger response. Also te that it was already kwn COVID-19 virus uses host proteins to replicate but exactly which proteins interact with viral RNA was t clear. study will help us understand process better.

Advertisement

Read: New Study Reveals Position Of Fleas On Tree Of Life; Here Is All That You Need To Kw
 

16:03 IST, December 27th 2020