Pfizer, Moderna, Oxford, Sputnik V: As Covid Vaccines publish results, here's what we know

2.  Moderna's Vaccine: (mRNA-1273)

Moderna's vaccine has shown an efficacy of 94.5% two weeks after second dose in an interim analysis

i.e. Dose 1 + 21 days + Dose 2 + 14 days -> 94.5%

study enrolled more than 30,000 people, in which 90 cases of Covid were observed in placebo group versus 5 cases in vaccine group.

Moderna plans to submit an emergency use authorisation application based on a final study of 151 cases, results of which are expected.

Moderna says stor and handling of vaccine can be done using existing infrastructure. vaccine is survivable in a standard medical refrigerator at 2-8 degree Celsius for up to 30 days and longer in a freezer (-4 to -20 degree Celsius) 

RE: Moderna's press release

3.Oxford vaccine (University of Oxford, Astrazeneca, Serum Institute):

Interim phase 3 data analysing 131 COVID cases presented two key findings:

first was that a half dose and n a full dose is 90% effective

i.e. Half Dose 1 + 21 days + Dose 2 + unspecified number of days -> 90% efficacy

second was that a full dose and n ar full dose is 62% effective

i.e. Dose 1 + 21 days + Dose 2 + unspecified number of days -> 62% efficacy

Combining data from two dosing regimens, efficacy was found to be 70.4%.

Oxford says, "Crucially, vaccine can be easily ministered in existing healthcare systems, stored at ‘fridge temperature’ (2-8 °C) and distributed using existing logistics."

RE: Oxford's press release

4. Russian vaccine Sputnik V:

A second interim analysis of phase 3 trial data analyses 39 confirmed cases  (31 from placebo group, 8 from vaccine group) in a study comprising 18,794 volunteers. It presents two results for same regimen:

On day 28 after first dose, a 91.4% efficacy was reported

i.e. Dose 1 + 21 days + Dose 2 + 7 days -> 91.4% efficacy

On day 42 after first dose, a 95% efficacy was reported

i.e. Dose 1 + 21 days + Dose 2 + 21 days -> 95% efficacy    

vaccine's vials must be stored at -18 degree Celsius or below, though a freeze-dried version is being tested that may be stored in a regular fridge (2-8 degree Celsius).

RE: Sputnik V press release

re are numerous or Covid vaccines in works, including from India and China, and y are unlikely to want to wait too long to publish ir own clinical trial data, interim or final. As per Worldometer, at time of publishing, almost 60 million Coronavirus cases have been reported worldwide with over 1.4 million people succumbing. re are an estimated 17 million active infections. vaccination of world's population is likely to be single-largest collective undertaking in history of humanity.