COVID-19: China's 'BBIBP-CorV' vaccine shows antibody response in elderly volunteers

In its preliminary results, China’s inactivated COVID-19 experimental vaccine candidate has turned back safe results after it elicited an antibody response. In a research published in journal Lancet Infectious Disease, experimental vaccine with 640 volunteers produced an immune response in early phase of double-blind, placebo-controlled, preclinical phase 1/2 trial at Shangqiu City Liangyuan District Center for Disease Control and Prevention in Henan Province, China. 

volunteers d between 18–80 years were first tested negative for serum-specific antibodies against SARS-CoV-2 at time of screening. y were n ministered a vaccine or placebo in a two-dose schedule. As per scientists,  participants d 60 and over were slower to respond as y took approximately 42 days to make antibodies, later detected in blood tests. However, people d 18 to 59 took almost 28 days to build an immune response. Professor Xiaoming Yang, le author of research from Beijing Institute of Biological Products Company Limited, said, “Protecting older people is a key aim of a successful COVID-19 vaccine as this group is at greater risk of severe illness from disease.”

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BBIBP-CorV induces antibody response

“However, vaccines are sometimes less effective in this group because immune system weakens with ,” researcher Yang said. It is encouraging to see that China’s BBIBP-CorV induces antibody responses in people d 60 and older, and we believe this justifies furr investigation. He furr ded that it is refore encouraging to see that BBIBP-CorV induces antibody responses in elderly individuals.

In first phase of study, firm ministered an optimal safe dose of BBIBP-CorV in192 participants d between 18 and 80, while in second phase 448 participants d between 18 and 59 were randomly assigned one eight-microgram shot of vaccine. As per researchers, serious verse events were reported within 28 days, and side-effects were reported. Only a small number of participants reported a mild fever, and major implication on organ functions of volunteers was reported. 

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