COVID-19: One shot of coronavirus vaccine not enough, say health experts

People will likely need two doses of COVID-19 vaccine and one shot won’t be eugh, Kathryn Edwards, scientific director of Vanderbilt Vaccine Research program said in a report published by School of Medicine. As in cases of Varicella, bacterial meningitis, Hepatitis A, B, Polio and many or diseases where more than one vaccine shot is required, COVID-19 would need two-dose series, a month or so apart with booster shots that may be required years later, according to  Vanderbilt Vaccine research. "MERS serology data suggest that by about three years, it could fe,” said Dr. Kathryn Edwards, however, she cited tests would tell if SARS-CoV-2 will need same booster injection patterns. 

ditionally, some or challenges in ministering two doses would be logistical, supply chain issues, like procuring PPE and test kits throughout pandemic. A blaring challenge would be to get everyone vaccinated, twice, according to US global analytics firm, Gallup's COVID-19 tracking survey, conducted with members of Gallup's probability-based panel. Associate director for immunization education with Immunization Action Coalition (IAC) at Vanderbilt University, Dr. Kelly Moore, was quoted as saying that while re is doubt that COVID-19 vaccination would be most complicated, largest vaccination program in human history, it would need a level of effort never tried before.

As many as six pharmaceutical companies have received worldwide funding and in US via Operation Warp Speed (OWS) to get vaccine shots available for every citizen, as per reports. While companies like AstraZeneca would enter Phase 3 trials, Moderna and Pfizer have begun largest human clinical trials for a COVID-19 vaccine ever. With over 30,000 volunteers, two companies have been ministering two doses of experimental vaccine candidate 28 days and 21 days apart, respectively. 

Meanwhile, according to reports, Johnson & Johnson's upcoming Phase 3 trials will have one shot given to volunteers, however, vavax which is yet to enter phase 3 will minister two doses. Although Safi, in its race to develop a new vaccine as well as manufacture and supply to curb short, hasn’t anunced doses it will experiment in its clinical trials. While re’s still a challenge to arrange two does vaccination for humungous world population, Moore reportedly said that companies will have to work with people to make process work. 

Logistic and Human issues

In US alone, at least 660 million doses for over 330 million Americans will have to eb manufactured as well as supplied, according to local media reports calculations. A professor of supply chain manment at rastern University, Na Sanders was quoted saying by US brocasters that companies were looking at necessary double shots. That's twice amount, and doubling those doses was a huge supply chain issue. One h to double everything in supply chain, Sanders stressed. syringes, vials, stoppers, needles, and getting everyone to get vaccinated twice and in time. “I’m worried,” Sanders said at a televised interview, citing current pandemic situation with shorts of Shingrix, a vaccine for shingles, an PPE, and ventilators. countries couldn’t get eugh supply of PPE kits and short of N95 masks hit, Sanders reminded. 

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Two-shot regimen h challenges

According to a CNN poll conducted in month of August for US, at least 40 percent of population in country refused to get vaccine. While re were hurdles of accommodation to minister two doses such as arrangements of mobile clinics, people mselves were difficult to convince to come twice. Director of Center for Infectious Diseases Research at Walter Reed Army Institute of Research,  Dr. Nelson Michael, was quoted as saying in a local media report that to incentivize people to come back  and get ar shot and for m to here to a two-shot regimen, looked like a challenging task. And se challenges are real, he ded.

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