Fast-acting insecticide by German scientists during WW II rediscovered

A new study in journal of American Chemical society explored chemistry as well as complicated and alarming history of a fast-acting insecticide, DFDT. researchers rediscovered insecticide created by German scientists during World War II. insecticide was used by German military for insect control in Soviet Union and rth Africa. According to Bart Kahr, a professor of chemistry at New York University claimed that department studied growth of crystals and uncovered impact of World War II on choice of DDT, kwn for its detrimental effect on environment and wildlife, as a primary insecticide in 20th century.

“We set out to study growth of crystals in a little-kwn insecticide and uncovered its surprising history, including impact of World War II on choice of DDT—and t DFDT—as a primary insecticide in 20th century,” 

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research

Two professors, Kahr and Michael Ward studied growth of crystals which furr led m to discover a new crystal form of torious insecticide DDT. new form developed by Kahr and Ward was found to be more effective against insects. It was smaller in amounts and potentially minimizing its environmental impact. y h prepared two solid forms of compound, a mo fluoro, and a difluoro analog. two professors tested m on fruit flies and mosquitoes, including mosquito species that carry malaria, yellow fever, Dengue, and Zika. solid forms of fluorinated DDT killed insects more quickly than did DDT and difluoro analog, kwn as DFDT, killed mosquitoes two to four times faster. professors h also me a detailed analysis of relative activities of solid-state forms of fluorinated DDT. y also ted that less rmodynamically stable forms in which crystals liberate molecules easily were more effective at quickly killing insects. 

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“Speed thwarts development of resistance,” said Ward, a senior author on study. “Insecticide crystals kill mosquitoes when y are absorbed through ps of ir feet. Effective compounds kill insects quickly, possibly before y are able to reproduce.” 

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