Published 19:50 IST, October 7th 2019

Johns Hopkins University celebrates Nobel laureate Gregg Semenza

The Johns Hopkins University School of Medicine celebrated Nobel laureate Dr Gregg Semenza for groundbreaking basic research in the field of medicine.

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Johns Hopkins University School of Medicine is celebrating one of its top researchers, Dr. Gregg Semenza, who shares this year's bel Prize for medicine for his work on how genes respond to low levels of oxygen. Semenza's dean, Paul B. Rothman, says his "groundbreaking basic research has been inspired largely by what he has seen in clinic" at Hopkins. university says that work has "far-reaching implications in understanding impacts of low oxygen levels in blood disorders, blinding eye diseases, cancer, diabetes, coronary artery disease, and or conditions."

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Shared award with two ors

63-year-old Semenza shares award with William G. Kaelin Jr., professor of medicine at Harvard University and Dana-Farber Cancer Institute who did his specialist training in internal medicine and oncology at Johns Hopkins, and Sir Peter J. Ratcliffe, professor at Oxford University and at Francis Crick Institute. Johns Hopkins University President Ronald J. Daniels calls it a momentous day, and says y're immensely proud of Semenza's passion for discovery, an example of school's commitment to creating new kwledge that helps make a better and more humane world.

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'How body apts to different levels of oxygen'

A member of bel Committee at Sweden’s Karolinska Institutet says this year’s award was given for “a fundamental basic science discovery about how body apts to different levels of oxygen.” Nils-Goran Larsson told Associated Press that although we are surrounded by oxygen “we have to apt to different oxygen levels — for instance, if we start living at higher altitude we have to apt and get more red blood cells, more blood vessels, and also in different disease processes regulation of oxygen and metabolism is very important.” Larsson says “people with renal failure often get hormonal treatment for anaemia. With this discovery system, re are alternative ways of doing this and developing similar treatments.”

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Dr. Andrew Murray of University of Cambridge says three winners of bel prize in medicine “revealed elegant mechanisms by which our cells sense oxygen levels and respond to fluctuations. In a statement on Monday, Murray said that hypoxia — when body doesn’t have eugh oxygen — is a characteristic of numerous diseases including heart failure, chronic lung disease and many cancers. He said work of Dr. William G. Kaelin Jr, Dr. Gregg Semenza and Dr. Peter Ratcliffe has “paved way to greater understanding of se common, life-threatening conditions and new strategies to treat m.”

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18:48 IST, October 7th 2019