COVID-19 vaccine induces broad antibody, T cell functions with two-dose regimen: Oxford

Researchers at Oxford University on December 17 said that its COVID-19 vaccine manufactured by AstraZeneca induces bro antibody and T cell functions with a two-dose regimen. university cited data from Phase I/II clinical trials of ChOx1 nCoV-19 coronavirus vaccine as evidence in an official release. According to findings published in journal Nature Medicine, University of Oxford said that in order to achieve immune response from its experiment candidate, pharmaceutical firm AstraZeneca activated two key elements of immune system. First, neutralizing antibody against coronavirus spike protein, and second robust T cell mechanism. 

“This highly detailed analysis of immune responses to ChOx1 nCoV-19 furr underpins potential of this vaccine to induce protection against COVID-19 disease and provides ditional reassurance of safety of this approach,” le author of one of papers, Professor Katie Ewer said in release.

Citing recent data from its subsequent phase III trials, she said, that vanced immunological techniques helped researchers understand cellular and antibody-mediated mechanisms that contribute to protection afforded by AstraZeneca vaccine. According to Oxford, researchers investigated two booster dose schedules in Phase III trials.

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‘Dose sparing’ strategy

Participants were ministered with a standard dose, which was followed by a second full standard dose and a separate standard dose followed by a lower dose. university called regimen a  ‘dose sparing’ strategy. “Researchers show lower reactogenicity such as sore arm to eir booster dose, and increased immune system responses,” Oxford claimed. It stated that AstraZeneca shifted to two-dose regimen in its ongoing Phase III trials.

Booster doses induce a more robust antibody response than a single dose, Oxford proposed, ding that many notable antibody functions were also triggered by vaccine. researchers also detailed T cell and antibody responses generated by ChOx1 nCoV-19 in report. y furr stated that ChOx1 nCoV-19 vaccine-induced Th1 cytokines rar than Th2 cytokines. Th1 cytokines allowed T cells in participant’s body to generate ‘signals’ to rest of immune system to fight SARS-coV-2.

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